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ZOE was initially released in most territories with a demo version of , the second installment of Hideo Kojima's popular stealth-based action game. Because of this association, initial sales figures could be counted as misleading; many buyers simply wanted the demo. A great many copies of ZOE appeared on "pre-owned" shelves of major gaming stores when the full version of Metal Gear Solid 2 was released.
One sequel exists, Zone of the Enders: The Second Runner (known as Anubis: Zone of the Enders in Japan), also for the PlayStation 2. There was also a spin-off turn-based strategy title named Zone of the Enders: The Fist of Mars , and an anime series named ZOE: 2167 IDOLO .
While ZOE focusses mostly on the loss of innocence of a child faced with having to kill to survive, IDOLO and The Fist of Mars explore issues surrounding terrorism.