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The town was incorporated in 1871 and was named after Joseph Walker, who settled in this area in 1850. On January 1 1999, it became part of the Municipality of Brockton.
The town of Walkerton became suddenly famous throughout Canada in May 2000 after the town's water supply became contaminated with E. coli bacteria from farm runoff. Seven people died and at least 2,300 people, more than 40% of the population at the time, became ill.
Following a thorough inquiry by Justice Dennis O'Connor, much of the blame was laid at the door of the operators of the water supply. In particular:
The Ontario Provincial Government was also blamed for this incident for their hasty privatization of public water testing labs and for ignorning warnings that this move could put people's lives at risk.
A tightening of procedures for water supply was instituted throughout Ontario as a result. The many lessons learned from this incident were described by Kim Vicente in his book The Human Factor.
A similar outbreak struck North Battleford, Saskatchewan in 2001.