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Vitamin C is a water- soluble vitamin used by the body for several purposes. Most animals can synthesize their own vitamin C, but some animals, including guinea pigs, humans, and other primates, cannot. Vitamin C was first isolated in 1928, and in 1932 it was proved to be the agent which prevents scurvy.
Vitamin C is the L-enantiomer of ascorbic acid. Commercial vitamin C is often a mix of ascorbic acid, sodium ascorbate and/or other ascorbates. See the ascorbic acid article for a description of the molecule's chemical properties.
The need to include fresh plant food in the diet to prevent disease was known from ancient times. Native peoples living in marginal areas incorporated this into their medicinal lore. For example, infusions of pine needles are used in the arctic zone, or the leaves from species of drought-resistant trees in desert areas.
Through history the benefit of plant food for the survival of sieges and long sea voyages was recommended by enlightened authorities. In the seventeenth century Richard Woodall , a ship's surgeon to the British East India Company, recommended the use of lemon juice as a preventive and cure in his book "Surgeon's Mate". The early eighteenth century DutchDutch redirects here. For other uses, see Dutch (disambiguation). The Netherlands ( Dutch: Nederland is the European part of the Kingdom of the Netherlands, a constitutional monarchy. It is located in northwestern Europe and borders the North Sea, Belgium writer, Johannes Bachstrom gave the firm opinion that "scurvy is solely owing to a total abstinence from fresh vegetable food, and greens; which is alone the primary cause of the disease."
thumb CitrusSpecies ''Citrus maxima Pomelo Citrus medica Citron Citrus reticulata Mandarin & Tangerine Major hybrids ''Citrus x aurantifolia Lime Citrus x aurantium Bitter orange Citrus x bergamia Bergamot Citrus x hystrix Kaffir lime Citrus x ichangensis Ichang lemo fruit were one of the first sources of Vitamin C used by ship's surgeons The first attempt to give scientific basis for the cause of scurvy was by a ship's surgeon in the British Royal NavyThe Royal Navy is the navy of the United Kingdom. It operates a number of aircraft carriers, destroyers, frigates, fifteen nuclear submarines, and various other ships, as well as aircraft and Britain's amphibious forces, the Royal Marines. The Royal Navy, James LindJames Lind ( 1716 1794) was a medical researcher and discoverer of treatment for scurvy. He was author of 'A Treatise of the Scurvy' ( 1753) External link Lind, James Lind, James., who at sea in May 1747Events January 31 The first venereal diseases clinic opens at London Dock Hospital April 9 The Scottish Jacobite Lord Lovat was beheaded by axe on Tower Hill, London, for high treason; he was the last man to be executed in this way in Britain May 3 Battle provided some crew members with lemon juice in addition to normal rations while others continued on normal rations alone. In the history of science this is considered to be the first example of a controlled experiment comparing results on two populations of a factor applied to one group only with all other factors the same. The results conclusively showed that lemons prevented the disease. Lind wrote up his work and published it in 1753Events January 1 Britain and its colonies adopt the idea that 1st January should be New Year's Day, following adoption of the Gregorian calendar in September 1752. The concept was first conceived in 1582, but suffered from slow public adoption. April 5 Fo.
Lind's work was slow to be noticed, partly because he gave conflicting evidence within the book and partly because of social inertia in some elements at the British admiralty who saw care for the well-being of ships' crew as a sign of weakness. It was 1795 before the British navy adopted lemon or lime juice as standard issue at sea. (This practice is probably what led to the nickname limey for British people, especially British sailors.)
The name "antiscorbutic" was used in the eighteenth and nineteenth centuries as general term for those foods known to prevent scurvy, even though there was no understanding of the reason for this. These foods include lemons, limes, and oranges; sauerkraut, salted cabbage, malt, and portable broth were employed with variable effect. James Cook relied on sauerkraut to prevent the disease on his voyages of exploration.
In 1907, Alex Holst and Theodore Frohlich , two Norwegian biochemists studying beriberi contracted aboard ship's crews in the Norwegian Fishing Fleet, wanted a small test mammal to substitute for the pigeons then used. They fed guinea pigs the test diet, which had earlier produced beriberi in their pigeons, and were surprised when scurvy resulted instead. Until that time scurvy had not been observed in any organism apart from humans, and it was considered an exclusively human disease.
In 1928 the arctic anthropologist and adventurer Vilhjalmur Stefansson attempted to prove his theory of how Eskimo ( Inuit) people are able to avoid scurvy with almost no plant food in their diet. This had long been a puzzle because the disease had struck European Arctic explorers living on similar high-meat diets. Stefansson theorised that the native peoples of the Arctic got their vitamin C from meat and offal that was raw or minimally cooked. Starting in February 1928, for one year he and a colleague lived on an animal-flesh-only diet under medical supervision at New York's Bellevue Hospital ; they remained healthy.
In the early twentieth century, the Polish-American scientist Casimir Funk conducted research into deficiency diseases, and in 1912 Funk developed the concept of vitamins, for the elements in food which are essential to health. Then, from 1928 to 1933, the Hungarian research team of Joseph L Svirbely and Albert Szent-Gyorgyi and, independently, the American Charles Glen King , first isolated vitamin C and showed it to be ascorbic acid.
In 1933- 1934, the British chemists Sir Walter Norman Haworth and Sir Edmund Hirst and, independently, the Polish Tadeus Reichstein, succeeded in synthesizing the vitamin, the first to be artificially produced. This made possible the cheap mass production of vitamin C. Haworth was awarded the 1937 Nobel Prize for Chemistry largely for this work.
In 1959 the American J.J. Burns showed that the reason some mammals were susceptible to scurvy was the inability of their liver to produce the active enzyme L-gulonolactone oxidase , which is the last of the chain of four enzymes which synthesise ascorbic acid.