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Malignancies of the internal organs can reach an advanced stage before giving symptoms. Stomach cancer, for example, can remain symptomless while metastatizing. One of the first visible spots where these tumors metastatise is the left supraclavicular lymph node. The left supraclavicular node is the classical Virchow's node because it is on the left side of the neck that the lymphatic drainage of most of the body enters the venous circulation into the left subclavian vein .

Differential diagnosis of an enlarged Virchow's node includes lymphoma and infectionInfection" is also the title of an episode of the television series Babylon 5; see Infection (Babylon 5). An infection is the detrimental colonization of a host organism by a foreign species. The colonizing organism interferes with the normal functioning (e.g. of the arm).