| Senator | Party | From
| To |
| John Chandler | Democrat | 1820 | 1829 |
| Peleg SpraguePeleg Sprague ( April 27, 1793— October 13, 1880) was an American politician from the U. state of Maine. Sprague was born in Duxbury, Massachusetts. In 1812 he graduated from Harvard University, and studied law in Litchfield, Connecticut. Sprague was admi | National Republican | 1829 | 1835 |
| John Ruggles | Democrat | 1835 | 1841 |
| George Evans | Whig | 1841 | 1847 |
| James W. Bradbury | Democrat | 1847 | 1853 |
| William P. FessendenWilliam Pitt Fessenden ( October 16, 1806— September 8, 1869) was an American politician from the U. state of New Hampshire. Fessenden was a Whig (later a Republican) and member of the Fessenden political family. He served in the U. House of Representativ | Whig, Republican | 1854 | 1864 |
| Nathan A. Farwell | Republican | 1864 | 1865 |
| William P. FessendenWilliam Pitt Fessenden ( October 16, 1806— September 8, 1869) was an American politician from the U. state of New Hampshire. Fessenden was a Whig (later a Republican) and member of the Fessenden political family. He served in the U. House of Representativ | Republican | 1865 | 1869 |
| Lot M. Morrill | Republican | 1869 | 1876 |
| James G. BlaineJames Gillespie Blaine ( January 31, 1830 January 27, 1893) was a U. Representative, U. Senator from Maine and a two-time United States Secretary of State. He also ran for President of the United States, obtaining the 1884 Republican nomination, but never | Republican | 1876 | 1881 |
| William P. Frye | Republican | 1881 | 1911 |
| Obadiah Gardner | Democrat | 1911 | 1913 |
| Edwin C. Burleigh | Republican | 1913 | 1916 |
| Bert M. Fernald | Republican | 1916 | 1926 |
| Arthur R. Gould | Republican | 1926 | 1931 |
| Wallace H. White Jr. | Republican | 1931 | 1949 |
| Margaret Chase Smith | Republican | 1949 | 1973 |
| William D. Hathaway | Democrat | 1973 | 1979 |
| William S. Cohen | Republican | 1979 | 1997 |
| Susan M. Collins | Republican | 1997 | |