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Born Michael Andrew Fox in Edmonton, Alberta, Canada, he adopted the J as a homage to character actor Michael J. Pollard, his real middle initial being "A". He has written an autobiographical book, called Lucky Man, about his experience of young-onset Parkinson's disease.
Notable roles include the Back to the Future movies, Mars Attacks!, Teen Wolf, and the TV series Family Ties and Spin City. He is the voice of Stuart Little in the series of movies based on the popular book by E. B. White; Chance in the Homeward Bound series; and Milo Thatch in .
In 2000 he announced that he would be retiring from the lead role of Spin City after being diagnosed with Parkinson's disease. He has since become a prominent advocate and fundraiser for stem cellUniversity of Wisconsin-Madison. Stem cells are primal, undifferentiated cells which have the potential to produce any kind of cell in the body. Medical researchers believe stem cells have the potential to change the face of human disease by being used to research, which he believes may one day help sufferers of Parkison's and other debilitating illnesses.
He has recently created a pilot for a sitcom series entitled Hench at HomeHench at Home is an ABC sitcom created, written and executive produced by Canadian comedian Michael J. Fox chose to semi-retire from acting due to his case of Parkinson's disease. The pilot for this show has been picked up by the ABC network. Hench at Hom.
Fox married actress Tracy Pollan in 1988.