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Northup was reportedly mentioned in the 1860 Federal US census with the following address:
Town: Queensbury, County: Warren, State: NY, P.O. Glen Falls.
He was absent from the 1865 New York census but his wife Ann was reportedly still living at the same address at that time.
The best available evidence indicates that he disappeared in 1863 while staying in Boston to give lectures. Many of those researching his disappearance have formed the opinion that Northup may have been kidnapped or killed by persons unknown while in Boston. Others feel that the sudden disappearance of a well known public figure would have been noticed and since his health was probably declining due to his years of captivity under harsh conditions, he may well have simply died of natural causes. Research into the ultimate fate of Northup continues.