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He was born to a modest family in Albisola, near Savona, Liguria. He joined the Franciscan Order, an unlikely choice, and his intellectual qualities were revealed while he was studying philosophy and theology at the University of Pavia. He went on to lecture at many eminent Italian universities. He was made Minister General of the Franciscan order in 1464. In 1467 he was made a Cardinal by Pope Paul II.
With his election, and after some ineffective sorties against the Turks in Smyrna, where fund-raising energy was more successful than half-hearted attempts to storm Smyrna and some attempts at unification with the Russian Orthodox Church, he turned to temporal issues and dynastic considerations. Sixtus continued the fruitless arguing with Louis XI of France, who continued to uphold the Pragmatic Sanction of Bourges (1438), that provided royal consent to papal decrees before they were promulgated in France, a cornerstone of the independence of the Gallican ChurchThe term Gallican Church usually refers to the Roman Catholic Church in France from the time of the Declaration of the Clergy of France ( 1682) to that of the Civil Constitution of the Clergy ( 1790) during the French Revolution. The related term Gallican that could never be shifted, while Louis maneuvered to replace Ferdinand I of NaplesFerdinand I of Naples should not be confused with Ferdinand I of the Two Sicilies, a latter king of Naples. Ferdinand I ( 1423 January 25, 1494), also called Don Ferrante was the King of Naples and the natural son of Alfonso V of Aragon and I of Sicily an with a French prince, which the Pope as a princely strategist could not permit.
Like a number of Popes, Sixtus was guilty of nepotism. In the fresco (illustrated, left) he is accompanied by his Della RovereThe Italian della Rovere family of the Renaissance supplied two popes: Francesco della Rovere, Pope Sixtus IV, 1471- 1484 Juliano della Rovere, Pope Julius II, 1503- 1513. and RiarioRiario was the name of three famous nephews of Francesco della Rovere, who reigned as Pope Sixtus IV. Girolamo Riario (Savona 1443 Forli 1488), Lord of Imola and Forli; The " Pazzi conspiracy" in Florence, 1478, had him as intended beneficiary, once Loren nephews, not all of whom were made cardinals: the apostolic pronotary Raffaele Riario (on his right), the future pope Julius II (pontiff from 1503 to 1513) standing before him, and Girolamo Riario and Giovanni della Rovere behind the kneeling Platina, author of the first Humanist history of the Popes. In his territoral aggrandizement of the Papal StatesThe Papal States Gli Stati della Chiesa or Stati Pontificii "States of the Church") is one of the historical states of Italy before its unity under the crown of Savoy and comprised those territories over which the Pope was the ruler in a civil as well as his nephew Cardinal Raffaele Riario, for whom the Palazzo della Cancelleria was constructed, was a leader in the 1478 failed "Pazzi conspiracyThe Pazzi family were old Tuscan nobles who had become Florentine bankers in the 14th century. Though Andrea dei Pazzi was the patron for Brunelleschi's chapter house for the Franciscans at Santa Maria Novella, which we know as the Pazzi Chapel, the Pazzi" to assassinate Lorenzo de' Medici and his brother and replace them Florence with the other nephew, Girolamo Riario. The archbishop of Pisa, a main organizer of the plot, was hanged on the walls of the Florentine Palazzo della Signoria, and Sixtus replied with an interdict and two years' of war with Florence. He also encouraged the Venetians to attack Ferrara, which he wished to obtain for another nephew. The angered Italian princes allied to force Sixtus to make peace, an act which annoyed Sixtus immensely.
As a temporal prince, who constructed stout fortresses in the Papal States Sixtus committed himself rather scandalously to Venice's aggression against the duchy of Ferrara, which he incited the Venetians to attack in 1482; their combined assault was interdicted by an alliance of Sforza Milan, Medici Florence, and ther King of Naples, his hereditary ally and usual strongarm of the Papacy. For refusing to desist from the very hostilities that he had instigated (and for being a dangerous rival to Della Rovere Papal ambitions in the Marche, Sixtus placed Venice under interdict in 1483.
Sixtus consented to the Spanish Inquisition issued a bull in 1478 that established an Inquisitor in in Seville, under political pressure from Ferdinand of Aragon, who threatened to withhold military support from his kingdom of Sicily. Nevertheless, Sixtus quarrelled over protocol and perogatives of jurisdiction, was unhappy with the excesses of the Inquisition and took measures to condemn the most flagrant abuses in 1482. In ecclesiastical affairs, Sixtus IV instituted the feast (December 8) of the Immaculate Conception of the Virgin Mary. He formally annulled (1478) the reformist decrees of the Council of Constance.
As a civic patron in Rome, even the anti-papal chronicler Stefano Infessura agreed that Sixtus must be admired. The Sistine Chapel was sponsored by Sixtus, as was the Sistine Bridge, to facilitate the integration of with the heart of old Rome. He also had San Vitale rebuilt in 1475, and refounded, enriched and enlarged the Vatican Library. He had Regiomontanus attempt the first sanctioned reorganization of the Julian calendar and called Josquin des Prez to Rome for his music. His bronze funerary monument in St Peter's Basilica, like a giant casket of goldsmith's work, is by Antonio Pollaiuolo