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Sigma factor (σ factor) is an initiation factor that binds to RNA polymerase and promotes attachment to promoter sites on DNA.Structure
Sigma factor has four main regions:
N----------C
1 2 3 4
- Region 1 regulates interaction with DNA.
- Region 2 binds RNAP and binds to the -10 promoter site.
- Region 4 binds to the -35 promoter site.
Molecular genetics
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