Home > Rhabdomyolysis

A large number of drugs may cause rhabdomyolysis through several mechanisms, such as myotoxicity (for example, animal toxins , antibiotics, statins, alcohol, etc), circulatory ischemia, hyperpyrexiaHyperpyrexia is the medical term for an excessive and unusual elevation of body temperature, or high fever (also called a hyperthermia . Some of the more common causes of hyperpyrexia include excessive exposure to heat or the sun (also called heat hyperpy, long duration muscle rigidity and others. Drug-induced rhabdomyolysis is more common nowadays than in the past, due to the introduction of increasingly more potent drugs into clinical practice. Any drug which directly or indirectly impairs the production or use of adenosine triphosphateFor other uses of the initials ATP, see ATP (disambiguation Adenosine triphosphate ATP is the nucleotide known in biochemistry as the " molecular currency" of intracellular energy transfer; that is, ATP is able to store and transport chemical energy withi (ATP) by skeletal muscle, or increases energy requirements so as to exceed ATP production, can cause rhabdomyolysis (Larbi, 1998).

Severe cases of rhabdomyolysis often result in myoglobinuria , a condition where the myoglobinMyoglobin is a single-chain protein of 153 amino acids, containing a heme ( iron-containing porphyrin) group in the center. With a molecular weight (MW) of 16,700, it is the primary oxygen-carrying pigment of muscle tissues. Unlike the blood-borne hemoglo from muscle breakdown spills into the urine, making it dark, or "tea colored" (myoglobin contains ironThis article is about metallic iron. For the ironing device, see ironing manganese iron cobalt Fe Ru Full table General Name, Symbol, Number iron, Fe, 26 Chemical series transition metal Group, Period, Block 8 (VIIIB), 4 , d Density, Hardness 7874 kg/m3,, like hemoglobinHaemoglobin ( BE) or hemoglobin ( AE), is the iron-containing oxygen-transport metalloprotein in the red cells of the blood in mammals and other animals. The molecule consists of globin, the apoprotein, and four haem groups, an organic molecule with an ir, giving muscles its characteristic red color). This condition can cause serious kidney damageAcute renal failure ARF is a rapid loss of renal function, characterised by oliguria (although an or nonoliguric ARF can occur) and derangements in body fluid balance and electrolyte levels. It is a serious kidney disease and treated as a medical emergenc in severe cases. The injured muscle also leaks potassiumpotassium calcium Na K Rb Full table General Name, Symbol, Numberpotassium, K, 19 Series alkali metals Group, Period, Block 1(IA), 4 , s Density, Hardness 856 kg/m3, 0. 4 Appearance silvery white Atomic properties Atomic weight 39. 0983 amu Atomic radius, leading to hyperkalemia, which may cause fatal disruptions in heart rhythm. In addition, myoglobin is metabolically degraded into potentially toxic substances for the kidneys. Massive skeletal muscle necrosis may further aggravate the situation, by reducing plasma volumes and leading to shock and reduced bloodflow to the kidneys.