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The office of Prime Minister was created when the Central African Republic became an autonomous territory of France in 1958. It was originally the highest post of the Central African Republic, though France did maintain a governor in the territory. In 1960, the Central African Republic declared its independence. David Dacko held both the Prime Minister and newly created President of the Central African Republic posts briefly before eliminating the Prime Minister position and placing all executive power in the office of the President.
President Jean-Bédel Bokassa restored the office of Prime Minister to assist him in governing the country in 1975, shortly before he declared himself Emperor. The post lasted until Emperor Bokassa was overthrown by a coup.
The creation of the modern position occurred in 1991, when President André Kolingba was forced to relinquish some of the executive power. This constitution has survived through a number of coup attempts, including the successful overthrow of President Ange-Félix Patassé's government by the military under François Bozizé.
| 1. | Barthélemy Boganda | 8 December 1958 | 29 March 1959Events January-February January 1 Cultivars of plants named after this date must be named in a modern language, not in Latin. January 1 Cuba: Fulgencio Batista flees Havana when forces of Fidel Castro advance January 2 CBS Radio cuts four soap operas: Bac |
| 2. | Abel GoumbaAbel Goumba (born 1927) is the Vice President of the Central African Republic under Francois Bozize. He was Prime Minister in the 1950s, and was appointed prime minister again in 2003 after a coup ousted the previous government. He has stressed the import | 2 April 1959Events January-February January 1 Cultivars of plants named after this date must be named in a modern language, not in Latin. January 1 Cuba: Fulgencio Batista flees Havana when forces of Fidel Castro advance January 2 CBS Radio cuts four soap operas: Bac | 30 April 1959Events January-February January 1 Cultivars of plants named after this date must be named in a modern language, not in Latin. January 1 Cuba: Fulgencio Batista flees Havana when forces of Fidel Castro advance January 2 CBS Radio cuts four soap operas: Bac |
| 3. | David Dacko | 1 May 1959 | 12 November 1960 |
| 1. | Elisabeth Domitien | 2 January 1975 | 7 April 1976 |
| 2. | Ange-Félix Patassé | 8 December 1976 | 14 July 1978 |
| 3. | Henri Maïdou | 14 July 1978 | 26 September 1979 |
| 4. | Bernard Ayandho | 26 September 1979 | 22 August 1980 |
| 5. | Jean-Pierre Lebouder | 12 November 1980 | 4 April 1981 |
| 6. | Simon Narcisse Bozanga | 4 April 1981 | 1 September 1981 |
| 1. | Edouard Frank | 15 March 1991 | 4 December 1992 |
| 2. | Timothée Malendoma | 4 December 1992 | 26 February 1993 |
| 3. | Enoch Derant Lakoué | 26 February 1993 | 25 October 1993 |
| 4. | Jean-Luc Mandaba | 25 October 1993 | 12 April 1995 |
| 5. | Gabriel Koyambounou | 12 April 1995 | 6 June 1996 |
| 6. | Jean-Paul Ngoupande | 6 June 1996 | 30 January 1997 |
| 7. | Michel Gbezera-Bria | 30 January 1997 | 1 February 1999 |
| 8. | Anicet Georges Dologuélé | 1 February 1999 | 1 April 2001 |
| 9. | Martin Ziguélé | 1 April 2001 | 15 March 2003 |
| 10. | Abel Goumba | 23 March 2003 | 12 December 2003 |
| 11. | Célestin Gaombalet | 12 December 2003 | Current |