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Phospholipase A2 catalyses the first step in the formation of arachidonic acid, the precursor of all eicosanoids ( leukotrienes, prostaglandins).
The PDB code for phospolipase A2 is 1CJY; the EC code is EC 3.1.1.4.
(Bacillus Cereus: PDB 1AH7, EC 3.1.4.3) Phospholipase C is a key enzyme in phosphatidyl inositol metabolism. It is activated by either G proteins (making it part of a G protein-coupled receptor signal transduction pathway) or by transmembrane receptors with intrinsic or associated tyrosine kinase activity. It converts phosphatidyl inositol to either inositol triphosphateInositol triphosphate (also commonly known as inositol trisphosphate or triphosphoinositol; abbreviated InsP or IP), together with diacylglycerol, is a second messenger molecule used in signal transduction in biological cells. It is made by hydrolysis of or diacylglycerolDiacylglycerol is a second messenger molecule made by phospholipase C (a membrane-bound enzyme), together with inositol triphosphate. Although inositol triphosphate diffuses into the cytosol, diacylglycerol stays close to the plasma membrane, due to its h.
EC 3.1