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In the USA ozone therapy is illegal, as the FDA has not approved its use on humans. It is considered to be quackery by the mainstream medical and science communities. At least one death has been attributed to application of ozone through insufflation in the USA. Ozone has been found to convert cholesterol in the blood stream to plaque (which causes hardening and narrowing of arteries). Ozone has been studied extensively, and found to be carcinogenic to some animals (and not others), and a mutagen to some bacteria. On the plus side, ozone is produced by white blood cells and the roots of marigolds to assist in fighting attacks on foreign bodies.