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A second peak in incidence occurs in the elderly, usually associated with an underlying bone pathology such as Paget's disease, medullary infarct , or prior irradiation.
Standard therapy is a combination of surgery and chemotherapy.
Osteosarcoma also occurs in dogs and typically afflicts middle aged dogs with long limbs (for example, Greyhounds and German Shepherds). One key difference between osteosarcoma in dogs and humans is that the cancer is far more likely to spread to the lungs in dogs.
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