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In the 80s and 90s, with support from Oregon's Senator Mark Hatfield, the university grew significantly. Research centers were founded to focus on the following areas:
The university grew in other ways as well. In 1992, the longest suspended pedestrian skybridge in North America, with a length of 660 feet (200 m), opened on the Marquam Hill campus, connecting OHSU and the Veteran's Affairs Medical Center. About the same time the university opened a number of outpatient primary care facilities, first on campus (the Physician's Pavilion) and then in clinics throughout the Portland metropolitan area.
In 1998, the university dedicated the Mark Hatfield Research Center. It also assumed control of an affiliated primate research center now known as the Oregon National Primate Research Center, located in Washington County.
In 2001, OHSU changed its name to Oregon Health and Science University as part of a merger it undertook with the Oregon Graduate Institute of Science and Technology in Washington County.
With the Marquam Hill (nicknamed Pill Hill) campus running out of room for expansion, beginning in 2003 OHSU announced plans to expand into the North Macadam district of Portland. North Macadam, also called the South Waterfront district, is an urban renewal district lying east of the Marquam Hill, south of city center, and along the Willamette River. The new Portland Aerial Tram has been planned to connect the two campuses.