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Myoglobin is a single-chain protein of 153 amino acids, containing a heme ( iron-containing porphyrin) group in the center. With a molecular weight (MW) of 16,700, it is the primary oxygen-carrying pigment of muscle tissues. Unlike the blood-borne hemoglobin, to which it is structurally related, this protein does not exhibit cooperative binding of oxygen. Instead, the binding of oxygen by myoglobin is unaffected by the oxygen tension in the surrounding tissue. In 1957, John Kendrew and associates successfully determined the structure of myoglobin by high-resolution X-ray crystallography.For this discovery, John Kendrew shared the 1962 Nobel Prize in chemistry with Max Perutz.
1 Role in disease
MyoglobinMyoglobin is a single-chain protein of 153 amino acids, containing a heme ( iron-containing porphyrin) group in the center. With a molecular weight (MW) of 16,700, it is the primary oxygen-carrying pigment of muscle tissues. Unlike the blood-borne hemoglo is the putative protein that causes acute renal failureAcute renal failure ARF is a rapid loss of renal function, characterised by oliguria (although an or nonoliguric ARF can occur) and derangements in body fluid balance and electrolyte levels. It is a serious kidney disease and treated as a medical emergenc in rapid breakdown of muscle (e.g. rhabdomyolysisRhabdomyolysis is the breakdown of skeletal muscle due to injury. The injury can be from physical damage to the muscle, but significant cases of rhabdomyolysis are more commonly due to high fever or hyperthermia, metabolic disorders, excessive exertion, c, severe crush trauma, malignant hyperthermiaMalignant hyperthermia is a life-threatening condition resulting from a genetic sensitivity of skeletal muscles to volatile anaesthetics and depolarizing neuromuscular blocking drugs that occurs during or after anaesthesia. The incidence has been reported, status epilepticusEpilepsy (sometimes referred to as a seizure disorder is a chronic neurological condition characterized by recurrent unprovoked seizures. The condition is named from the Greek epilepsia ("a taking hold of or seizing"). It is commonly controlled with medic and neuroleptic malignant syndromeNeuroleptic malignant syndrome is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic (antipsychotic) drugs. Symptoms include high fever, sweating, unstable blood pressure, stupor, muscular rigidity, and auton), due to its toxicity to renal tubular epithelium.
Myoglobin is a sensitive marker for muscle injury, making it a potential marker for myocardial infarctionplaque builds up in the walls of blood vessels. Acute myocardial infarction AMI or MI , commonly known as heart attack is a serious, sudden heart condition characterized by varying degrees of chest pain, weakness, sweating, nausea, and vomiting, sometimes in patients with chest painIn medicine, chest pain is a symptom of a number of serious conditions and is generally considered a medical emergency, unless the patient is a known angina pectoris sufferer and the symptoms are familiar. Causes Important cardiovascular and pulmonary cau. Its specificity and the cost of the analysis has prevented its widespread use.
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