Index: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
LogP is a measure of differential solubility of a compound in two solvents. The log ratio of the concentrations of the solute in the solvent is called LogP or the Partition Coefficient. The most well known of these partition coefficients is the one based on the solvents Octanol and Water. The octanol-water partition coefficient is a measure of the hydrophobicity and hydrophilicity a substance. In the context of drug-like substances, hydrophobicity is related to absorption, bioavailability, hydrophobic drug- receptor interactions, metabolism and toxicity.1 Application
2 Prediction
see also: QSAR
3 See also
ADMEADME is short for absorption, distribution, metabolization/ metabolism and excretion and describes the effectiveness of a pharmaceutical compound within an organism. The four criteria are all critical with respect to the success of the compound as a drug:, CLogPCLogP is shorthand for 'computed LogP', a measure of differential solubility or rather hydrophobicity as the octanol/water partition coefficient. See also computational chemistry, ADME.
4 External links
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