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Larkana is as old as Civilization of Moen-Jo-Daro that dates back to five thousand years. Larkana was renown for its product of Cloth in those days.its product of cloth was shifted from Moen-jo-Daro to the rest of countries via water ways. in the mean time same cloth was used for mummification in Egypt. Thus credit for unparalleled technological advancement of Moen-jo-Daro goes to its trade of cloth. Aryans had come in Sindh in 2234 B.C. They had settled in different part of Sindh. they while crossing Larkana, reached Bhanbhoor. Jhokar-jo-Daro is a proof of Aryan visit. Different people came in Sindh but non could eliminate the Tradition of Aryans till teachings of Gotam Bodh spread for and wide in 480s B.C whoses proof is found in Moen-jo-Daro that was a center of wership for Bhudism. Sikandar attacked Sindh in 330 B.C. His forces had crossed little village known as Mahota. it was named by his forces as Maota in Greek. After Greeks Sindh was ruled by Gupt Family from 320 A.D to 525 A.D.
In this period Barhunasim uprooted to Bhudism to some extent. Soomras had occupied whole of Sindh except Bakhar and Multan. In 1182 A.D Sultan Shuhabudin Gori occupied Bakhar and Multan. In the mean while, Larkana was the part of Bakhar(Now known as Sukkur). After Soomra Clan, Sama Clan ruled over Sindh and Thatta was made as capital of Sindh , Jam Nizamdin was best rulers of Sindh. In the mean time, Chandia Community had hold over Larkana. Besides, Chandias had helped Jam Nizamuddin against their opponent Shah Beg Argon. Thus, Chandias were rewarded heavily for their contribution. It was in this period that Larkana was named as Chandka. However, after demise of Jam Nizamuddin, Shah Beg Argon started ruling over Sindh. Larkana city is purely result of Construction of Cannal “Ghaar Wah”. In late 16th century, Kalhoras started their rule. In their rule, Shah Baharo was a ruler of Larkana. After end of Kalhora rule, period of Talpur came and Nawab Wali Mohammad Khan was made Governor of Larkana.
In 1843 A.D, The English occupied Sindh. They divided Sindh in three parts Vis Karachi, Hyderabad and Shikarpur. Larkana was the part of Shikarpur and Dadu was part of Larkana. In 1930 A.D. Dadu was made separate District and Larkana got its present shape during Historic movement for Pakistan. Larkanians took active role in movement of Khilafat and Higrat so on the whole Larkana is always been the center of political activity in Sindh.