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Korsakoff's presents with symptoms of severe anterograde and retrograde amnesia, as well as confabulation. These symptoms are caused by damage to mammillary bodies and other brain regions due to deficiency of thiamine ( Vitamin B1). This is most often caused by chronic alcoholism, though other conditions including severe malnutrition have been known to cause it. When Wernicke's encephalopathy accompanies Korsakoff's syndrome, the combined syndrome is called the Wernicke-Korsakoff syndrome.
Pathologically, there is neuronal loss , gliosis , and hemorrhage in mammillary bodies. Intravenous (IV) or intramuscular (IM) injectionInjection has multiple meanings: In mathematics, the term injection refers to an injective function. Medical injection . Injection molding industrial process. Fuel injection in internal combustion engines. of thiamine is used to treat this condition, though recovery is slow and often incomplete.