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In Oklahoma, I-240 runs 16.22 miles west from Interstate 40 to Interstate 44 in southern Oklahoma City. After its terminus in SW Oklahoma City, I-240 becomes Interstate 44 and Airport Road toward Will Rogers World Airport.
The part between I-35 and current I-44 was already done in 1965. A loop along current I-44 up to OK 66, then east to I-35 again, was a planned extension of I-240, for a total of 31.76 miles but was rejected in favour of the current designation.
Major destinations along the route include Crossroads Mall , the suburb of Moore, and the heavily populated Southside of Oklahoma City.