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An International Terrestrial Reference Frame (ITRF) is a realization of the IERS. New ITRF solutions are produced every few years, using the latest mathematical and surveying techniques to attempt to realize the IERS as precisely as possible. Due to experimental error, any given ITRF will differ very slightly from any other realization of the ITRF.
Practical navigation systems are in general referenced to a specific ITRF solution, or to their own coordinate systems which are then referenced to an ITRF solution.
The ITRS and ITRF solutions are maintained by the International Earth Rotation and Reference Systems Service ( IERS).
-- need lots about the details of ITRS and ITRF