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Interleukins are a group of cytokines that are expressed by white blood cells ( leukocytes, hence the -leukin) as a means of communication (inter-). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency.A list of interleukins with function:
- IL-1: secreted by macrophages, induces acute phase reaction
- IL-2: secreted by T cells, stimulates growth and differentiation of T cell response. Can be used in immunotherapy to treat cancer.
- IL-3 : secreted by T cells, stimulates bone marrow stem cells.
- IL-4 : involved in proliferation of B cells, and the development of T cells and mast cells. Important role in allergic responses.
- IL-5 : role in stimulation of B cells, eosinophil production, IgA production
- IL-6 : secreted by macrophages, induces acute phase reaction
- IL-7 : B and T cell stimulation
- IL-8 : Neutrophil chemotaxisChemotaxis is the phenomenon in which bacteria, other organisms, or single cells of multicellular organisms to direct their movements according to certain chemicals in their environment. This is important for bacteria to find food (for example, glucose) b
- IL-9 : stimulates mast cells
- IL-10Interleukin-10 (IL-10 or IL10), also known as hmuan cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine, capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNF and GM-CSF by cells such as ma: inhibits Th1 cytokine production
- IL-11 : acute phase protein production
- IL-12 : NK cell stimulation, Th1 cells induction
Immunology
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