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Insulin potentiation therapy (IPT) is a therapeutic modality used by some physicians to treat cancer and other diseases, using insulin in combination with other drugs, including chemotherapy agents. IPT dates from 1930, and has been in use continuously since by a small, but now rapidly growing number of doctors. Currently more than 100 physicians in 22 countries have IPT certification. IPT is not yet accepted by the medical mainstream, although several scientific studies, and one small clinical trial for breast cancer, appear to support its claims.

One theory about how IPT works for treating cancer is that, since at least some types of cancer cells have far more insulin receptors than normal cells, insulin tricks them into more rapidly absorbing chemotherapy drugs from the blood. Another theory is that insulin stimulates more of the cancer cells to start growing and dividing, thus making them more sensitive to the effects of chemotherapy. As a result, lower doses of chemotherapy agents are used, with significantly fewer toxic effects to the patient. IPT induces a temporary lowering of the patient's blood sugar, which is thought to also aid chemotherapy uptake and effectiveness.

Physicians using this method have claimed dramatic results with few or no side effects. This type of treatment is not experimental in the usual sense, but is an " off-label" use of existing agents. Rigorous clinical studies still need to be performed to prove the effectiveness of IPT.

The principal proponent of this technique is Dr. Donato Perez Garcia (1958-), grandson of the discoverer, Dr. Donato Perez Garcia (1896-1971), who claims that IPT is especially effective with breast cancer. He suggests that it is also effective with a number of other cancers, including small-cell lung cancer and prostate cancer. Essentially, if a cancer can be significantly affected by existing chemotherapy drugs, then insulin potentiation therapy may be effective, without major side effects.

The original, largest, and most comprehensive website about IPT: http://IPTQ.com

Listings for doctors who have IPT training: http://GetIPT.com

A critical perspective is found at http://www.quackwatch.org

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Topics: Insulin Potentiation Therapy, Insulin Pump, Insulin like Growth...

Insulincarbon; green: oxygen; blue: nitrogen; pink: sulphur. The blue/purple ribbons denote the skeleton [-N-C-C-]n in the protein's amino acid sequence H-[-NH-CHR-CO-]n-OH where R is the part protruding from the skeleton in each amino acid. Insulin ( Latin insu	Insulin pumpAn insulin pump is a device used for administering insulin in the treatment of diabetes mellitus. The device consists principally of three parts : the pump itself including controls, processing module, and batteries delivery tube to carry the insulin need	Insulin-like growth factorThe insulin-like growth factors (IGFs) are polypeptides with high sequence similarity to insulin. They can trigger the same cellular responses as insulin, including mitogenesis in cell culture. IGF-II is thought to be a primary growth factor required for
Insulin resistanceIn medicine, insulin resistance denotes a decompensation of glucose homeostasis where the tissues appear to be less responsive to insulin. Introduction In patients who use insulin, "insulin resistance" is production of antibodies against insulin that lead	Insulin potentiation therapyInsulin potentiation therapy (IPT) is a therapeutic modality used by some physicians to treat cancer and other diseases, using insulin in combination with other drugs, including chemotherapy agents. IPT dates from 1930, and has been in use continuously si	Insulin receptorIn molecular biology, the insulin receptor is a transmembrane receptor that is activated by insulin. It belongs to the large class of tyrosine kinase receptors. Two alpha subunits and two beta subunits make up the insulin receptor . The beta subunits pass
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