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Imipramine is the first antidepressant to be developed in the late 1950s. It is not as commonly used today but sometimes used to treat major depression as a second-line treatment.

Some common side effects of the drug include: tremors, dry mouth, blurred vision, constipation, insomnia, drowsiness , perspiration, flushing and weight gain.

Imipramine, a tertiery amine, inhibits the reuptake of serotonin more so than most secondary amine tricyclic, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally.