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• Our Lady of Guadalupe, according to Roman Catholic canon, one of the three recognized appearances of the Virgin Mary which appeared to Saint Juan Diego (the first canonized Saint of native american origin) in the mount of Tepeyac near Mexico City on December 12, 1531. It is the most venered religious image in Mexico, and is also recognized as the country and the Americas patron saint. The anniversary of the appearance is conmemorated every year on December 12th.
• The Basilica of Guadalupe , built in honor of Mary of Guadalupe, is the largest Basilica in America, located in Mexico City.
• Guadalupe is a town in Spain (pop. 2,325), in the Extremaduran province of Cáceres. It is the location of a convent that was an important pilgrimage site.
• Isla de Guadalupe is a small island owned by Mexico on the Pacific ocean.
• Guadalupe (short "Lupe" or "Lupita") is a very common name in Spanish speaking countries (primarily Mexico), used in honor to the Blessed Virgin of Guadalupe. Although most commonly a female name, it also can be assigned to males.

Guadalupe is not to be confused with the French overseas département of Guadeloupe.