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Men are affected more than twice as often as women, with most infections occurring in people aged 20 to 40 years. The disease is seldom seen in children or the elderly.
It is thought that anal intercourse, rather than vaginal intercourse, is the most frequent source of infection. About 50 percent of infected men and women have lesions in the anal area.
U.S. NIH on Granuloma inguinale
Sexually-transmitted diseases