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It is shot in black and white.
Johnny Depp's character is named William Blake, but the character is not initially familiar with the works of the 18th-19th century artist and writer of the same name. One of the more memorable lines in the film comes from Depp's character before he kills a man; after the victim asks if he's William Blake, Blake replies, "Yes I am. Do you know my poetry?" and then shoots. The poetry of William Blake is quoted by Gary Farmer's character, a Native American named Nobody, at several points in the film.
Robert Mitchum, Billy Bob Thornton, Iggy Pop, Gabriel Byrne, Crispin Glover, John Hurt, Alfred Molina, and Steve Buscemi also have minor roles or cameos.