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Clostridium tetani

Kingdom:	Bacteria
Division:	Firmicutes
Class:	Clostridia
Order:	Clostridiales
Family:	Clostridiaceae
Genus:	Clostridium
Species:	tetani

Binomial name

Clostridium tetani

Clostridium tetani is a gram positive, spore-forming, obligate anaerobic, rod-shaped bacterium of the phylum firmicutes. C. tetani's appearance on gram stain is said to resemble tennis rackets or drumsticks. Found in nature as spores in soil or parasitising the gastrointestinal tracts of animals, these bacteria cause serious toxicity in humans. See excellent article on tetanus.

1 History

Tetanus, the disease, was known to the ancients, who recognized the relationship between wounds and fatal muscle spasms. In 1884, the strychnine-like toxin of tetanus was isolated from free-living, anaerobic soil bacteria. In 1890, tetanus toxoid was developed, providing active immunization against the illness. This is our modern tetanus vaccine.

2 Characteristics

C. tetani is an obligately anaerobic bacillus that stains gram positive in fresh cultures, but may stain gram negative in older cultures. During growth, the germ possesses many flagellae and have limited mobility. Two toxins are elaborated, tetanospasminTetanospasmin is the neurotoxin produced by the vegetative spore of Clostridium tetani in anaerobic conditions, causing tetanus. It is sometimes called spasmogenic toxin or simply tetanus toxin (TeTx). tetani also produces the exotoxin tetanolysin, the ef and tetanolysin , the latter of which is of uncertain toxicity and significance. As the organism matures, it develops a terminal spore, giving it the characteristic tennis racket appearance. Spores are exteremely hardy but can be rendered harmless by iodineIodine (from the Gr. Iodes meaning "violet"), is a chemical element in the periodic table that has the symbol I and atomic number 53. This is an insoluble element that is required as a trace element for living organisms. Chemically, iodine is the least re, hydrogen peroxideProperties General Name Hydrogen peroxide Chemical formula H O Appearance Colourless liquid Physical Formula weight 34. 0 amu Melting point 272. 4 °C) Boiling point 423 K (150 °C) Density 1. 4 ×103 kg/ m3 Solubility miscible Thermochemistry ΔH0 -136 or heat and pressure treatment ( autoclavingAn autoclave is a device that uses steam to sterilise equipment and other objects. This means that all bacteria, viruses, fungi, and spores are inactivated. Prions are not necessarily destroyed. However, in 2003 scientists discovered a single-cell organis). From a clinical viewpoint, growing the organism from a wound is of no significance.

3 Epidemiology

There are about one million cases of tetanus reported worldwide and about 70 in the United States annually. Most cases in the US are in the elderly who have allowed their innoculations to lapse, whereas most cases in developing countries are in newborns.

4 Toxicity

Tetanospasmin is similar in structure to botulinum toxin, but very different in effect. It is a zinc-dependent metalloproteinase. There is a heavy protein chain and a light chain connected by a disulfide bridge. The heavy chain attaches to the cellular receptor, and the light chain produces the toxic effects. It enters the central nervous system by binding to the ends of axons and travelling up the axon to the cell bodies. There, it blocks the release of neurotransmitter from inhibitory neurons to motor cells. The motor neurons then fire because of unopposed action of excitatory neurons, leading to diffuse muscle spasm.

See also: Tetanus

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Topics: Clostridium Tetani, History, Characteristics, Epidemiology...

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