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Ciprofloxacin is the generic international name for the synthetic antibiotic manufactured and sold by Bayer Pharmaceutical under the brand name Cipro® (and other brand names in other markets, e.g. veterinary drugs ), belonging to a group called fluoroquinolones.Ciprofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an
enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.
Ciprofloxacin is a broad-spectrum antibiotic that is active against both
Gram-positive and Gram-negative bacteria.
- Enterobacteriaceae
- Vibrio
- Hemophilus influenzae
- Neisseria gonorrhoeae
- Neisseria menigitidis
- Moraxella catarrhalis
- Brucella
- Mycoplasmagenitalium M. hominis M. pneumoniae etc. Mycoplasma is a genus of small bacteria which lack cell walls. Several species are pathogenic in humans, including M. pneumoniae which is an important cause of pneumonia and other respiratory disorders, and M.
- Campylobactersee text Campylobacter is a genus of Gram-negative bacteria. Species Campylobacter fetus Campylobacter jejuni Campylobacter coli Campylobacter sputorum Campylobacter mucosalis Campylobacter concisus Campylobacter nitrofigilis Campylobacter laridis Campylo
- Helicobacter pyloriHelicobacter pylori is a bacterium that infects the mucus lining of the human stomach. Many peptic ulcers and some types of gastritis are caused by H. pylori infection, although most humans are infected and will never develop symptoms. The bacterium is he
- Mycobacterium intracellulare
- Legionella sp.
- Pseudomonas aeruginosa
- Bacillus anthracisBacillus anthracis is a rod-shaped Gram-positive bacterium of size about 1 by 6 micrometres, and is the cause of the disease known as anthrax. anthracis was the first bacterium ever to be shown to cause disease, by Robert Koch in 1877. The specific name a - that causes anthraxAlternate meanings in Anthrax (disambiguation Anthrax is an acute infectious disease caused by the bacteria Bacillus anthracis and is highly lethal in its most virulent form. Anthrax most commonly occurs in wild and domestic herbivores, but it can also oc
Weak activity against:
- Streptococcus pneumoniaeStreptococcus pneumoniae is a species of Streptococcus that is a major human pathogen. It was recognized as a major cause of pneumonia in the 1880s, and is the subject of many humoral immunity studies. The organism was originally named Diplococcus pneumon
No activity against:
- Bacteroides
- Burkholderia cepacia
- Enterococcus faecium
- and others
The major adverse effect seen with use of is gastrointestinal irritation , common with many antibiotics. Because of its general safety, potency and broad spectrum activity, ciprofloxacin was initially reserved as a 'last-resort' drug for use on difficult and drug-resistant infections . As with any antibiotic, however, increasing time and usage has led to an increase in ciprofloxacin-resistant infections, mainly in the hospital setting. Also implicated in the rise of resistant bacteria is the use of lower-cost, less potent fluoroquinolones, and the widespread addition of ciprofloxacin and other antibiotics to the feed of farm animals , which leads to greater and more rapid weight gain, for reasons which are not clear.
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