Science  People  Locations  Timeline
Index: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Home > Ciprofloxacin


 

Ciprofloxacin is the generic international name for the synthetic antibiotic manufactured and sold by Bayer Pharmaceutical under the brand name Cipro® (and other brand names in other markets, e.g. veterinary drugs ), belonging to a group called fluoroquinolones.

Ciprofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an

enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.

Ciprofloxacin is a broad-spectrum antibiotic that is active against both

Gram-positive and Gram-negative bacteria.

Weak activity against:

No activity against:

The major adverse effect seen with use of is gastrointestinal irritation , common with many antibiotics. Because of its general safety, potency and broad spectrum activity, ciprofloxacin was initially reserved as a 'last-resort' drug for use on difficult and drug-resistant infections . As with any antibiotic, however, increasing time and usage has led to an increase in ciprofloxacin-resistant infections, mainly in the hospital setting. Also implicated in the rise of resistant bacteria is the use of lower-cost, less potent fluoroquinolones, and the widespread addition of ciprofloxacin and other antibiotics to the feed of farm animals , which leads to greater and more rapid weight gain, for reasons which are not clear.



Read more »

Non User