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Home > Bradykinin


Bradykinin is a peptide of the kinin group of proteins and consists of 9 amino acids. The kininogenase kallikrein makes bradykinin by proteolytic cleavage of its kininogen precursor, high-molecular weight kininogen (HMWK).

It is a potent vasodilator, causes contraction of non-vascular smooth muscle, and increased vascular permeability and also causes pain. It has similar actions to that of histamine.

The amino acid sequence of bradykinin is: arg - pro - pro - gly - phe - ser - pro - phe - arg.

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