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Grierson was born in 1826, the youngest of five siblings. He became afraid of horses when at age eight he was kicked and nearly killed by a horse. In 1851, he became music teacher and band leader in Jacksonville, Illinois. He married Alice Kirk of Youngstown, Ohio on September 24, 1854. The couple had seven children, four of whom survived to adulthood. Alice died August 14, 1888; Grierson later married Lillian Atwood King, a widow, July 28, 1897. During his life, he had homes in Jacksonville, Illinois, Fort Concho, and a summer home at Omena, Michigan. In 1907 he suffered a debilitating stroke; he died in 1911 and was buried in Jacksonville, Illinois.
As a Colonel he led Grierson's Raid in April and May of 1863, a brilliant piece of American Civil War maneuvering. Became major general of volunteers, moving up from a volunteer aide. Commander of the District of Northern Alabama.
Colonel Grierson organized the Tenth United States Cavalry, one of two mounted regiments composed of black enlisted men and white officers.
Called the Buffalo Soldiers: "The only White officer who supports the unit is Regimental Commanding Officer Colonel Benjamin Grierson. Ostracized by other officers for his enthusiastic command of the African-American troops, Grierson believes in the abilities, dedication, and record of performance of the Buffalo Soldiers and declines offers to lead at any other post. General Pike offers to relieve Grierson "of this self-imposed exile and have him commanding a real cavalry regiment within a month," but Grierson refuses" - TNT's "Buffalo Soldiers".
Colonel Grierson is a prominent figure in Turner Network Television's the "Buffalo Soldiers".
The part of Colonel Marlowe, played by John Wayne in the movie The Horse SoldiersThe Horse Soldiers ( 1959) (set in the American Civil War), directed by John Ford, is a film about a Union Cavalry detachment, lead by Colonel John Marlowe ( John Wayne), which is sent behind the Confederate enemy lines in strength to destroy a railroad a is losely based on Grierson.