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Acid chlorides are very reactive, the presence of the chlorine on the carbonyl carbon makes it a very good electrophile, since both the oxygen and chlorine are strongly electron withdrawing, giving the carbon a large partial positive charge. This means even a weak nucleophile can attack the carbon. Since a chloride ion is a good leaving group, this is a very useful compound synthetically, it can be used to prepare any carboxylic acid derivative: an acid anhydride, an ester or an amide by reacting acid chlorides with: a salt of a carboxylic acid, an alcohol or an amine respectively. Acid chlorides will also react with waterDrinking water This article focuses on water as we experience it every day. The water (molecule) article describes water from a scientific and technical perspective. Water is an abundant substance on Earth. It exists in many forms, such as sea, rain, and or a Gilman reagentA Gilman Reagent is a lithium and copper (diorganocopper) reagent compound, , where R is an organic radical. These are useful because they react with chlorides, bromides, and iodides to replace the halide group with an R group. This is extremely useful in (lithium diorganocopper compound).