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AMPA receptors are composed of four subunits, designated as GluR1-GluR4 (alternatively called GluRA-GluRD), and is probably a tetramer . Most receptors are either homomers of GluR1 or GluR3, or symmetric 'dimer of dimers' of GluR2 and either GluR1 or GluR3 . The AMPA receptor s' permeability to calcium and other ions such as sodium and potassium, is governed by the GluR2 subunit. Post- transcriptional modification to the so-called Q/ R editing site of the GluR2 mRNA determines whether the resulting AMPAR will be calcium-permeable. In particular, GluR2(Q) is permeable to calcium, while the calcium permeability of GluR2(R) is negligible. Almost all of the GluR2 subunits in the CNSCNS can refer to: in air traffic control, Communication, Navigation, Surveillance often associated with the acronym ATM ( Air Traffic Management) as CNS/ATM . the central nervous system. are of the GluR2(R) form. This means that the principal ion gated by AMPA receptors is sodium.