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A .44 Magnum revolver will generally accept both .44 Magnum and .44 Special ammunition, but a weapon designed for .44 Special will only accept those rounds, due to the longer overall length of a .44 Magnum cartridge.
This cartridge was made notorious through its use by the " Dirty Harry" character in the Clint Eastwood film of the same name. However, it was not then and is not now "the most powerful handgun [cartridge] in the world."